Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1 genes in cardiac cells by mechanical load
نویسندگان
چکیده
Sampsa Pikkarainen, Heikki Tokola, Risto Kerkelä, Mika Ilves, Markus Mäkinen, Hans-Dieter Orzechowski, Martin Paul, Olli Vuolteenaho, and Heikki Ruskoaho Departments of Pharmacology and Toxicology, Physiology, and Pathology, Biocenter Oulu, University of Oulu, Oulu, Finland; and Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany
منابع مشابه
Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.
Mechanical stretch and para- and/or autocrine factors, including endothelin-1, induce hypertrophy of cardiac myocytes and proliferation of fibroblasts. To investigate the effect of mechanical load on endothelin-1 production and endothelin system gene expression in neonatal rat ventricular myocytes and fibroblasts, we exposed cells to cyclic mechanical stretch in vitro (0.5 Hz, 10-25% elongation...
متن کاملManuscript R-00559-2005/R1 Inverse Regulation of Preproendothelin-1 and Endothelin-Converting Enzyme-1β Genes in Cardiac Cells by Mechanical Load
Mechanical stretch and paraand/or autocrine factors, including endothelin-1, induce hypertrophy of cardiac myocytes and proliferation of fibroblasts. To investigate the effect of mechanical load on endothelin-1 production and on endothelin system gene expression in neonatal rat ventricular myocytes and fibroblasts, we exposed cells to cyclic mechanical stretch in vitro (0.5 Hz, 10% to 25% elong...
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The rhythmic heart beat is coordinated by electrical impulses transmitted from Purkinje fibers of the cardiac conduction system. During embryogenesis, the impulse-conducting cells differentiate from cardiac myocytes in direct association with the developing endocardium and coronary arteries, but not with the venous system. This conversion of myocytes into Purkinje fibers requires a paracrine in...
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Alpha-adrenergic vasoconstriction in the coronary circulation is mediated through alpha-adrenoceptors on cardiac myocytes and subsequent release of endothelin, a very potent, long-lasting vasoconstrictor. Recent studies found that adult cardiac myocytes do not express the preproendothelin gene. Thus we hypothesized that alpha-adrenoceptor stimulation on the cardiac myocytes results in the produ...
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